Outcomes
Tools
The main three tools delivered at the end of the project are all connected and complementary.
Biomarkers identified as either critical components or proxies thereof in the CARE-IN-HEALTH Atlas and applied in the CARE-IN-HEALTH MCDSS will be included in the sensor technology for rapid, inexpensive, and easy phenotyping of inflammatory risk without relying on health care facilities.
CARE-IN-HEALTH ATLAS
platform to gather scientific evidence and understanding of health-to-disease transition
Research and Health care professionals
Open science practices will be a strategic priority for the project and a prime component of its methodology.
One milestone and main deliverable is a comprehensive, open access CARE IN-HEALTH Atlas hosting results and models generated from integrated epidemiological, multi-omics, and immunological data analyses within the project consortium.
An open access platform using Qlucore technical software solutions provided by P6-QLU and server space provided by P1-INSERM will be built. Raw human omics data and pseudonymized meta-data will be deposited in secure public repositories, e.g., Gene Expression Omnibus (GEO) Database, ProteomeXchange Consortium (PXD), the database of Genotypes and Phenotypes (dbGaP), European nucleotide archive (ENA), and Proteomics Identification Database (PRIDE). Large datasets will be deposited in openly accessible repositories that will further guarantee its sustainability after project end.
The approach to open science practices will take into account confidentiality requirements related to data protection and security, privacy law, respect for research freedom and integrity.
CARE-IN-HEALTH MCDS
application to improved guidelines for personalized prevention strategies
Health care professionals
The CARE-IN-HEALTH MCDSS application is a multi criteria decision support system (MCDSS), easy-to-use software solution for healthcare professionals with patient-friendly visualizations. The CARE-IN-HEALTH MCDSS tool will be a novel Information and Communication Technology (ICT) to assist healthcare professionals to optimize CVD prevention. Monitoring changes in biomarkers in relation to Polyunsaturated fatty acids (PUFAs) exposure to predict response and bioavailability will result in a potential to predict responders and non-responders at both baseline and follow-up.
The application will be effective through the development of the Qlucore software to create AI-powered, CVD-specific classifier models. CARE-IN-HEALTH MCDSS will be assessed by the consortium in the prospective POMEGA-2 trial and used in the RESOLVIN trial.
CARE-IN-HEALTH BIOSENSOR
first in class point of care tool to citizens own health management
Non-hospital-based healthcare professionals
A CArdiovascular DISease (CADIS) sensor system is capable of measuring, with high sensitivity, a panel of multiple biomarkers and low limit of detection with greatly reduced assay times, and a reduced footprint. However the current state of development of the CADIS-chip software is a simple Matlab program not suitable for non-technical users. The project objective is its development into a tablet/smartphone CADIS App.
The CArdiovascular DISease (CADIS) chip is a miniaturized portable biosensor system which combines a microfluidic sample processor chamber with an impedimetric electrochemical antibody/aptamer biosensor platform.
A whole blood sample is introduced into the microfluidic sample processor where the plasma is separated from the whole blood via a size exclusion effect induced by perpendicular plasma filtration channels and capillary forces. Biomarker capture probes are chemically immobilized, utilizing robust established surface chemistries, onto the WE surface and biomarker-probe binding causes measurable charge transfer resistance to the WE directly correlated to biomarker concentration.
With the aim to become the first point-of-care technology for ultrasensitive personalized inflammatory blueprinting and prediction of the health-to-CVD transition, the biosensor validation will be performed in the present project in the RESOLVIN prospective clinical.
Dissemination
The dissemination strategy of CARE-IN-HEALTH results will be developed in cooperation with all WPs and consortium partners to target all stakeholders, who will benefit from the prevention strategies foreseen. The Consortium will also implement mechanisms to solicit feedback from stakeholders so that project outcomes can be perfectly aligned with real-life needs.
Dissemination activities
Year 1
Presentations at 1-2 international conferences
Year 2
Presentations at 2-3 international conferences
1 article in nonspecialized press
Year 3
Presentations at 3-4 international conferences
1 article in nonspecialized press
1-2 Publication of consortium results
Year 4
Presentations at 4-5 international conferences
2 articles in nonspecialized press
1-2 Publication of consortium results
Year 5
Presentations at 7-8
international conferences
2 articles in nonspecialized press
1-2 Publication of consortium results
CARE-INHEALTH Symposium on CVD prevention
Targeted symposia
| Conferences | Targeted audience |
| European Society of Cardiology, American Heart, American College of Cardiology, ESC Preventive Cardiology | Cardiologists, Dieticians, CVD prevention decision-makers |
| CardioGenomics, Personalized Medicine | Geneticians, Personalized medicine, Precision tool diagnostics companies |
| European Congress of Immunology | Immmunologists |
| ASBMB Deuel, Bioactive lipids conference, Annual Drug Discovery Chemistry, Gordon Research Conference on Clinical Lipidomics | Lipid biochemists, cell biologists and pharmacologists |
| ESC Digital Summit, World Congress on Biosensors | Bioinformaticians, Digital health and biosensor developers, Biotechnology companies |
Communication
Internal communication (including web-based communication),external communication, annual meetings :
Effective collaboration and communication between all partners are crucial to ensure project progress and success.The actions, will focus on :
Effective communication of project’s progress among partners throughout the project’s lifetime
Effective communication of information regarding CARE-INHEALTH to appropriate external audiences, including clinicians, patients, citizens, scientific societies and policy makers
Networking with other studies or consortia sharing similar or complementary scientific, clinical and public health interests
Intellectual property management :
Details concerning protection and exploitation of new results will be integrated into the Consortium Agreement. CARE-IN-HEALTH consortium will ensure the knowledge will be managed properly, IP protected and exploited adequately and effectively by the appropriate partner.
Implementation of communication actions
| Target audience | Action | Tools |
| Scientific and clinical groups | Presentations at international congresses and Publication of project results in scientific journals | Specialized and non-specialized journals, blogs, forums, conferences, webinars, website |
| Patients | Information on project progress, get patient’s association contribution to the development of prevention strategies, obtain feedbacks on prevention strategies | Patient Day, website, questionnaires, Digital stories |
| Health care professionals | Identification of key demonstrators for adoption, Training in biosensor use before implementation | Workshops, website, Newsletters, webinars |
| Policy makers and scientific society | Identification of prerequisite for adoption, mapping of technical and legal requirement for implementation, demonstration of prevention strategies performance, | Focus groups, Newsletters, Workshops |
| General public, citizens | Information and project contribution to personalized prevention, management improvement for patient’s, family and society | Newletters, Patients Day, Social media, website, press releases, TV and radio interviews |
Communication activity during CARE-IN-HEALTH
Year 1
Website launch
Design/distribution Flyer & Poster
Press release
Social media
Year 2
Update
Update and Distribution
Press release
Status update
Year 3
Update
Update and Distribution
Press release
Status update
Workshop
CVD outreach day
Year 4
Update
Update and Distribution
Press release
Status update
Workshop
Focus group
Year 5
Update
Update and Distribution
Press release
Status update
Workshop
CVD outreach day
Consortium Symposium
Focus group